产品货号：
Z23699
中文名称：
过氧化物酶标记Plasminogen/PLG抗体
英文名称：
Anti-Plasminogen/PLG Antibody Peroxidase Conjugated
产品规格：
100μg
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-Plasminogen/PLG Antibody Peroxidase Conjugated |
| 指标别名 | Angiostatin;plasminogen;PLG |
| 克隆性 | Polyclonal |
| 检验物种 | human |
| 应用范围 | ELISA,WB |
| 基因名称 | PLG |
| 抗体来源 | Goat |
| 抗体类型 | IgG |
| 免疫原 | Plasminogen [Human Plasma] |
| 计算分子量 | 91kDa |
| 成分 | 0.02M Potassium Phosphate,0.15M Sodium Chloride,pH7.2,10mg/mL Bovine Serum Albumin (BSA) - Immunoglobulin and Protease free,0.01% (w/v) Gentamicin Sulfate.Do NOT add Sodium Azide! |
| 纯化方式 | Anti-Plasminogen is an IgG fraction antibody purified from monospecific antiserum by a multi-step process which includes delipidation,salt fractionation and ion exchange chromatography followed by extensive dialysis against the buffer stated above.Assay by immunoelectrophoresis resulted in a single precipitin arc against anti-Peroxidase,anti-Goat Serum as well as purified and partially purified Plasminogen [Human Plasma].Cross-reactivity against Plasminogen from other sources is unknown. |
| 浓度 | 1.0mg/mL by UV absorbance at 280nm |
| 产品形态 | Lyophilized |
| 保存条件 | Store vial at 4℃ prior to restoration.For extended storage aliquot contents and freeze at -20℃ or below.Avoid cycles of freezing and thawing.Centrifuge product if not completely clear after standing at room temperature.This product is stable for several weeks at 4℃ as an undiluted liquid.Dilute only prior to immediate use.Expiration date is one (1) year from date of opening. |
| 背景资料 | Plasmin is released as a zymogen called plasminogen (PLG) from the liver into the systemic circulation.Two major glycoforms of plasminogen are present in humans.Type II plasminogen is preferentially recruited to the cell surface over the type I glycoform.Conversely,type I plasminogen appears more readily recruited to blood clots.In circulation,plasminogen adopts a closed,activation resistant conformation.Upon binding to clots,or to the cell surface,plasminogen adopts an open form that can be converted into active plasmin by a variety of enzymes,including tissue plasminogen activator (tPA),urokinase plasminogen activator (uPA),kallikrein,and factor XII (Hageman factor).Fibrin is a cofactor for plasminogen activation by tissue plasminogen activator.Urokinase plasminogen activator receptor (uPAR) is a cofactor for plasminogen activation by urokinase plasminogen activator.The conversion of plasminogen to plasmin involves the cleavage of the peptide bond between Arg-561 and Val-562.Deficiency in plasmin may lead to thrombosis,as clots are not degraded adequately.Plasminogen deficiency in mice leads to defective liver repair,defective wound healing,reproductive abnormalities.In humans,a rare disorder called plasminogen deficiency type I is caused by mutations of the PLG gene and is often manifested by ligneous conjunctivitis. |
| Uniprot ID | P00747 |
| 基因名全称 | Plasminogen |
| 推荐稀释比 | ELISA:1:2,000 - 1:10,000 IHC:1:250 - 1:1,000 WB:1:500 - 1:2,500 |
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